Endocrine Abstracts

Introduction: Russell’s Viper is a venomous snake found in South and South East Asia. The snake bite causes coagulopathy, neurotoxicity, renal failure, local effects and even death. But hypopituitarism is an extremely rare complication1. There are only a few case reports from India and Burma and we report the first case from Sri Lanka.Case report: A 49 year old man from a remote part of Sri Lanka was bitten by a Russell’s viper 3 yea...

Background: Patients with thyroid abnormalities often also suffer with anxiety and depression. Our objectives in this study was to investigate prospectively the effect of thyroid dysfunction per se on quality of life and levels of depression and anxiety.Methods: A total of 102 patients who were referred to thyroid clinic were enrolled in the study in consecutive order. Enrollment criteria comprised patient aged 20–60 with no major life events, previ...

Hungry bone syndrome is common in tertiary hyperparathyroidism after parathyroidectomy. Less frequently, it has been described after thyroidectomy in patients with hyperthyroidism. We hereby report a case of hungry bone syndrome in a patient who suffers with Graves’ disease.A 44-year-old woman with a history of refractory Graves’ disease presented with 4 weeks history of shortness of breath, palpitations and peri-oral paraesthesia following tot...

Case History: Mr AT, a 54 year old male was referred by his GP in 2019 with a two year history of raised calcium. He initially sought medical attention for pain radiating from the left buttock to the knee. He had a background of hypertension and pre-diabetes and was on Nifedipine LA 3 mg OD and Furosemide 20 mg OD. He denied headaches, insomnia, concentrating problems, constipation, polyuria and polydipsia. He had no history of fractures nor renal stones. He was a non-smoker a...

Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) result in a severe form of psychomotor retardation (known as Allan-Herndon-Dudley syndrome, AHDS) due to compromised TH access to the CNS. Consequently, TH-dependent processes both during brain development and in the adult CNS such as adult hippocampal neurogenesis are impaired. Using mice deficient in Mct8, we recently demonstrated a diminished neurogenesis in the adult hippoca...

Introduction: Several studies have described ethnic differences in HbA1c. Non-Caucasian patients have been found to have a higher HbA1c than the Caucasian ones. These differences have often been attributed to disparities in access to medical care or quality of the care. However differences in HbA1C in ethnic minorities could also relate to biological factors so we looked at mean levels of glycaemia. The aim of our study was to observe if there is a similar correlation between ...

Adrenal lymphangiomatous cysts are rare, often found incidentally, but can also present in association with abdominal/loin pain or hypertension.1 They have occasionally been reported in association with hormone over secretion of either aldosterone, cortisol or catecholamines. We present a case of a 40-year-old serving soldier who was suddenly awoken with severe left sided abdominal and flank pain. Over the course of several months, he was forced to take time off wor...

Introduction: Not much has been reported about Idiopathic Postprandial syndrome, especially in Africa. Many cases are often wrongly diagnosed as reactive hypoglycemia. Idiopathic postprandial syndrome refers to signs and symptoms of hypoglycemia in the absence of low blood sugar occurring after meals and is of unknown cause. Clinical case: We report a case of Idiopathic Postprandial Syndrome in a 44-year old woman living in Nigeria. We present a 44-year-...

Background: While pituitary adenomas are the commonest Sella neoplasm, number of other entities should be considered in the differential diagnosis and the diagnosis is based on histopathological and immunohistochemical characteristics. Pituitary tumors with papillary architecture are uncommon and have limited differential diagnoses. Primary papillary epithelial tumor of the pituitary is a recently described histopathological entity with striking papillary architecture and TTF1...

Turner syndrome (TS) is the most common chromosomal anomaly in females and its occurrence is about 1:4000 live births. This is the only monomer disease that humans can survive (1). It is characterized by the presence of one X chromosome and a partial or complete loss of the second X chromosome. Clinical features of TS can vary, mainly classified into Growth failure, gonadal insufficiency, cardiovascular diseases, or learning disabilities. Short stature is the only phenotypic a...